Encourage • Empower • Leverage
2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016
| Title | Journal Information | PMID | Authors | PI | PI Institute |
|---|---|---|---|---|---|
| A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques | PNAS 117 (14) 7981-7989 | 32209664 | Michel C. Nussenzweig, Davide F. Robbiani | RU | |
| SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts | Nat Commun 12, 4611 (2021) | 34326333 | Matthew B. Greenblatt | WCM | |
| A TCR mimic monoclonal antibody for the HPV-16 E7-epitope p11-19/HLA-A*02:01 complex | PLoS ONE 17(3), March 17, 2022 | 35298559 | David A. Scheinberg | MSK | |
| A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors | ACS Med. Chem. Lett. 2022, 13, 3, 377–387 | 35300079 | Richard E. Phillips | MSK | |
| Transforming Academic Drug Discovery | Chem Bio Chem, Volume23, Issue8, April 20, 2022 | 35181980 | Peter T. Meinke | TDI | |
| Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates | J. Med. Chem. 2022, 65, 22, 15208–15226 | 36346696 | Levin/ Buck | WCM | |
| A TCR mimic monoclonal antibody reactive with the "public" phospho-neoantigen pIRS2/HLA-A*02:01 complex. | JCI Insight. 2022;7(5):e151624 | 35260532 | David A Scheinberg | MSK | |
| Comparing the Performance of Different AMBER Protein Forcefields, Partial Charge Assignments, and Water Models for Absolute Binding Free Energy Calculations | J. Chem. Theory Comput. 2022, 18, 4, 2616–2630 | 35266690 | David J. Huggins | David J. Huggins | TDI |
| Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors | J. Med. Chem. 2022, 65, 13, 9350–9375 | 35727231 |
Hao Zhang, John Ginn , Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin |
Gang Lin | WCM |
| Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold | ACS Chem. Neurosci. 2022, 13, 13, 1849–1856 | 35738565 |
Brian Reed, Michael Miller, Mayako Michino, Eduardo R. Butelman, Ariel Ben-Ezra, Philip Pikus, Michelle Morochnik, Yuli Kim, Amy Ripka, Joseph Vacca, Mary Jeanne Kreek |
Mary Jeanne Kreek | RU |
| Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs | PNAS, July 8, 2022 | 34035288 |
NathanielR. Kastan, Sanyukta Oak, Rui Liang, Leigh Baxt, Robert W. Myers, John Ginn, Nigel Liverton, David J. Huggins, John Pichardo, Matthew Paul, Thomas S. Carroll, Aaron Nagiel, Ksenia Gnedeva, A. J. Hudspeth |
A. J. Hudspeth | RU |
| Assessing the effect of forcefield parameter sets on the accuracy of relative binding free energy calculations | Front. Mol. Biosci., 12 September 2022 | 36225254 | Shan Sun, David J. Huggins | David J. Huggins | TDI |
| Small-molecule inhibition of the acyl-lysine reader ENL as a strategy against acute myeloid leukemia. | Cacer Discovery, Nov. 2, 2022 | 36053276 |
Yiman Liu, Qinglan Li, Fatemeh Alikarami, Declan R. Barrett, Leila Mahdavi, Hangpeng Li, Sylvia Tang, Tanweer A. Khan, Mayako Michino, Connor Hill, Lele Song, Lu Yang, Yuanyuan Li, Sheela Pangeni Pokharel, Andrew W. Stamford, Nigel Liverton, Louis M. Renzetti, Simon Taylor, Gillian F. Watt, Tammy Ladduwahetty, Stacia Kargman, Peter T. Meinke, Michael A. Foley, Junwei Shi, Haitao Li, Martin Carroll, Chun-Wei Chen, Alessandro Gardini, Ivan Maillard, David J. Huggins, Kathrin M. Bernt, Liling Wan |
Liling Wan | RU |
| Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential | Front. Physiol., 28 September 2022 | 36246105 |
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck |
Lonny R. Levin, Jochen Buck | WCM |
| Neuropeptide regulation of non-redundant ILC2 responses and tissue homeostasis | Nature, Nov. 2, 2022 | 36323781 |
Amy M. Tsou, Hiroshi Yano, Christopher N. Parkhurst, Tanel Mahlakõiv, Coco Chu, Wen Zhang, Zhengxiang He, Katja J. Jarick, Connie Zhong, Gregory G. Putzel, Mai Hatazaki, JRI IBD Live Cell Bank Consortium, Ivo C. Lorenz, David Andrew, Paul Balderes, Christoph S. N. Klose, Sergio A. Lira David Artis |
David Artis | WCM |
| Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer |
Science Translational Medicine | 35294260 | Tommy White, Abdul Khan, Paul Balderes, Ivo Lorenz | Brendan Stiles | WCM (former |
| Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization | Molecular Human Reproduction, Volume 27, Issue 9, September 2021 | 34463764 | Melanie Balbach, Lubna Ghanem, Thomas Rossetti, Navpreet Kaur, Carla Ritagliati, Jacob Ferreira, Dario Krapf, Lis C Puga Molina, Celia Maria Santi, Jan Niklas Hansen, Dagmar Wachten, Makoto Fushimi, Peter T Meinke, Jochen Buck, Lonny R Levin |
Buck/ Levin | WCM |
| Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) | ACS Medicinal Chemistry Letters | 34413957 | Makoto Fushimi, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A Foley, Michael Miller, Nigel J Liverton, David J Huggins, Peter T Meinke | Levin/Buck | WCM |
| Targeting allostery in the Dynein motor domain with small molecule inhibitors | Cell Chemical Biology | 34015309 | Yasuhiro Hirata, Yoshiyuki Fukase | Tarun Kapoor | RU |
| Deglycase-activity oriented screening to identify DJ-1 inhibitors | RSC Medicinal Chemistry | 34355187 | Efrat Finkin-Groner, Yoshiyuki Fukase, Shan Sun, Mayako Michino, David J. Huggins, Robert W. Myers | Yael David | MSK |
| Targeting eIF4A Dependent Translation of KRAS Signaling Molecules | Cancer Res. 2021 Feb 25;canres.2929.2020 | 33632898 | Mark Duggan, Yoshiyuki Fukase, Andrew W. Stamford, Peter T. Meinke | Hans-Guido Wendel | MSK |
| Whole cell active inhibitors of mycobacterial lipoamide dehydrogenase afford selectivity over the human enzyme through tight binding interactions | ACS Infect Dis. 2021 Feb 12;7(2):435-444 | 33527832 | Ginn, John; Sun, Shan; Michino, Mayako; Huggins, David; Liverton, Nigel; Imaeda, Toshihiro; Okamoto, Rei; Kuroita, Takanobu; Aso, Kazuyoshi; Stamford, Andrew; Foley, Michael; Meinke, Peter; | Nathan, Carl; Bryk, Ruslana | WCM |
| Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice | Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9279-9283 | 33433953 | John Ginn, Mayako Michino, Akinori Toita, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Kenjiro Sato, Kazuyoshi Aso, Peter Meinke | Gang Lin, Carl Nathan, Laura Kirkman | WCM |
| Recent Progress in Kappa and Mu Opioid Receptor Targeted Ligands | Medicinal Chemistry Reviews, 2020 Volume 55 | Chapter 4 | Brian Reed, Michael Miller | Mary Jeanne Kreek | WCM |
| A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques | Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7981-7989 | 32209664 | Van Rompay, K.; Coffey, L.; Kapoor, T.; Gazumyan, A.; Keesler, R.; Jurado, A.; Peace, A.; Agudelo, M.; Watanabe, J.; Usachenko, J.; Singapuri, A.; Immareddy, R.; Ardeshir, A.; Stuart, J.; Bournazos, S.; Ravetch, J.; Balderes, P.; Lorenz, I.; Esswein, S.; Keeffe, J.; Bjorkman, P.; Wang, Q.; Rice, C.; MacDonald, M.; Nussenzweig, M.; Robbiani, D. | Michel Nussenzweig Davide Robbiani |
RU |
| Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in post-mitotic mammalian tissues | Nat Commun. 2021 May 25;12(1):3100. doi: 10.1038/s41467-021-23395-3. | 34035288 | Kastan, N.; Gnedeva, K.; Alisch, T.; Petelski, A.; Huggins, D.; Chiaravalli, J.; Aharanov, A.; Shakked, A.; Tzahor, E.; Nagiel, A.; Segil, N.; Hudspeth, J. | James Hudspeth | RU |
| Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents | Biochemistry 2019, 58, 6, 833-847 | 30582694 | Bythrow, G.; Mohandas, P.; Guney, T.; Standke, L.; Germain, G.; Lu, X.; Ji, C.; Levendosky, K.; Sundaram Chavadi, S.; Tan, D.; Quadri, L. ACKNOWLEDGMENTS: Yasutomi Asano, Makoto Fushimi, Naoyoshi Noguchi, and Michael A. Foley | Derek S. Tan | MSK |
| Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration | Biol Reprod. 2020 Aug 4;103(2):176-182. doi: 10.1093/biolre/ioaa052. | 32307523 | Balback, M.; Makoto, F.; Huggins, D.; Steegborn, C.; Meinke. P.; Levin, L.; Buck, J. | Lonny Levin, Jochen Buck | WCM |
| Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance | Proc Natl Acad Sci U S A 115(29):E6863-E6870 | 29967165 | Kirkman, L.; Zhan, W.; Visone, J.; Dziedziech, A.; Singh, P.; Fan, H.; Tong, X.; Bruzual, I.; Hara, R.; Kawasaki, M.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Fernandez-Alvaro, E.; Guiang, L.; Sanz, L.; Mota, D.; Govindasamy, K.; Wang, R.; Ling, Y.; Tumwebaze, P.; Sukenick, G.; Shi, L.; Vendome, J.; Bhanot, P.; Rosenthal, P.; Aso, K.; Foley, M.; Cooper, R.; Kafsack, B.; Doggett, J.; Nathan, C.; Ling, G. | Lin | WCM |
| Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome | J Med Chem 62(20):9246-9253 | 31560200 | Zhan, W.; Hsu, H.; Morgan, T.; Ouellette, T.; Burns-Huang, K.; Hara, R.; Wright, A.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Ramjee, M.; Aso, K.; Menke, P.; Foley, M.; Nathan, C.; Li, H.; Lin, G. | Lin | WCM |
| Inhibition of 3-Phosphoglycerate Dehydrogenase (PHGDH) by Indole Amides Abrogates de novo Serine Synthesis in Cancer Cells | Bioorg Med Chem Lett. 2019 Sep 1;29(17):2503-2510 | 31327531 | Mullarky, E.; Xu, J.; Robin, A.; Huggins, D.; Jennings, A.; Noguchi, N.; Olland, A.; Lakshinarasimhan, D.; Miller, M.; Tomita, D.; Michino, M.; Su, T.; Zhang, G.; Stamford, A.; Meinke, P.; Kargman, S.; Cantley, L. | Cantley | WCM |
| ALTHEA Gold Libraries™: Antibody libraries for therapeutic antibody discovery | MAbs. 2019 Apr;11(3):516-531 | 30663541 | Valadon, P.; Perez-Tapia, S.; Nelson, R.; Guzman-Bringas, O.; Arrieta-Oliva, H.; Gomez-Castellano, K.; Pohl, M.; Almagro, J. | Juan Carlos Almagro | TDI |
| Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors | J Med Chem 62(13):6137-6145 | 31177777 | Zhan, W.; Visone, J.; Ouellette, T.; Harris, J.; Wang, R.; Zhang, H.; Singh, P.; Ginn, J.; Sukenick, G.; Wong, T; Okoro, J.; Scales, R.; Tumwebaze, P.; Rosenthal, P.; Kafsack, B.; Cooper, R.; Meinke, P.; Kirkman, L.; Lin, G. | Gang Lin | WCM |
| A Robust Method for the Purification and Characterization of Recombinant Human Histone H1 Variants | Biochemistry. 58(3):171-176 | 30585724 | Osunsade, A.; Prescott, N.; Herbert, J.; Ray, D.; Jmeian, Y.; Lorenz, I.; David, Y | David, Yael | MSK |
| Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience | 31313902 | Dunn, A.; Reed, B.; Erazo, J.; Ben-Ezra, A.; Kreek, M. Acknowledgement- Mike Miller | Kreek | RU |
| Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations | ACS Pharmacol Transl Sci. 2019 Aug 2;2(6):387-401 | 32259072 | Li, J.; Fukase, Y.; Yi, S.; Zou, W.; Munoz-Feliz, J.; Buitrago, L.; van Agthoven, J.; Zhang, Y.; Hara, R.; Tanaka, Y.; Okamoto, R.; Yasui, T.; Nakahata, T.; Imaeda, T.; Aso, K.; Zhou, Y.; Locuson, C.; Nesic, D.; Duggan, M.; Takagi, J.; Vaughan, R.; Walz, T.; Hodivala-Dilke, K.; Teitelbaum, S.; Arnaout, M.; Filizola, M.; Foley, M.; Coller, B. | Barry Coller | RU |
| Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action | Elife. 2017 May 19 | 28524820 | Steinman , J.; Santarossa, C.;Miller, R.; Yu, L.; Serpinskaya, A.; Furukawa, H.; Morimoto, S.; Tanaka, Y.; Nishitani, M.; Asano, M.; Zalyte, R.; Ondrus, A.; Johnson, A.; Ye, F.; Nachury, M.; Fukase, Y.; Aso, K.; Foley, M.; Gelfand, V.; Chen, J.; Carter, A.; Kapoor, T. | Tarun Kapoor | RU |
| Development of human cGAS-specific small molecule inhibitors for repression of dsDNA-triggered interferon expression | Nat Commun. 2019 May 21;10(1):2261 | 31113940 | Lama, L.; Adura, C.; Xie, W.; Tomita, D.; Kamei, T.; Kuryavyi, V.; Gogakos, T.; Steinberg, J.; Miller, M.; Ramos-Espiritu, L.; Asano, Y.; Hashizume, S.; Aida, J.; Imaeda, T.; Okamoto, R.; Jennings, A.;Michino, M.; Kuroita, T.; Stamford, A.; Gao, P.; Meinke, P.; Glickman, J.; Patel, D.; Tuschl, T. | Thomas Tuschl | RU |
| Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. | Proc Natl Acad Sci USA. 2019 Jun 11;116(24):11946-11955 | 31142647 | Xie, W.; Lama, L.; Adura, C.; Tomita, D.; Glickman, F.; Tuschl, T.; Patel, D. | Thomas Tuschl | RU |
| Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. | Biochemistry. 2018 Feb 27; 57(8): 1399–1409 | 29394041 | Singh PK, Kawasaki M, Berk-Rauch HE, Nishida G, Yamasaki T, Foley MA, Norris EH, Strickland S, Aso K, Ahn HJ. | Sid Strckland | RU |