Skip to Main Content

Publications

ANNUAL REPORTS

2020 | 2019 | 2018 | 2017 | 2016

 

PUBLICATIONS

Title Journal Information PMID Authors PI PI Institute
Expression of the mono-ADP-ribosyltransferase
ART1 by tumor cells mediates immune resistance
in non–small cell lung cancer
Science Translational Medicine 35294260 Tommy White, Abdul Khan, Paul Balderes, Ivo Lorenz Brendan Stiles WCM (former
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) ACS Medicinal Chemistry Letters 34413957 Makoto Fushimi, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A Foley, Michael Miller, Nigel J Liverton, David J Huggins, Peter T Meinke Levin/Buck WCM
Targeting allostery in the Dynein motor domain with small molecule inhibitors Cell Chemical Biology 34015309 Yasuhiro Hirata, Yoshiyuki Fukase Tarun Kapoor RU
Deglycase-activity oriented screening to identify DJ-1 inhibitors RSC Medicinal Chemistry 34355187 Efrat Finkin-Groner, Yoshiyuki Fukase, Shan Sun, Mayako Michino, David J. Huggins, Robert W. Myers Yael David MSK
Targeting eIF4A Dependent Translation of KRAS Signaling Molecules Cancer Res. 2021 Feb 25;canres.2929.2020 33632898 Mark Duggan, Yoshiyuki Fukase, Andrew W. Stamford, Peter T. Meinke Hans-Guido Wendel MSK
Whole cell active inhibitors of mycobacterial lipoamide dehydrogenase afford selectivity over the human enzyme through tight binding interactions ACS Infect Dis. 2021 Feb 12;7(2):435-444 33527832 Ginn, John; Sun, Shan; Michino, Mayako; Huggins, David; Liverton, Nigel; Imaeda, Toshihiro; Okamoto, Rei; Kuroita, Takanobu; Aso, Kazuyoshi; Stamford, Andrew; Foley, Michael; Meinke, Peter; Nathan, Carl; Bryk, Ruslana WCM
Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9279-9283 33433953 John Ginn, Mayako Michino, Akinori Toita, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Kenjiro Sato, Kazuyoshi Aso, Peter Meinke Gang Lin, Carl Nathan, Laura Kirkman WCM
Recent Progress in Kappa and Mu Opioid Receptor Targeted Ligands Medicinal Chemistry Reviews, 2020 Volume 55 Chapter 4 Brian Reed, Michael Miller Mary Jeanne Kreek WCM
A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7981-7989 32209664 Van Rompay, K.; Coffey, L.; Kapoor, T.; Gazumyan, A.; Keesler, R.; Jurado, A.; Peace, A.; Agudelo, M.; Watanabe, J.; Usachenko, J.; Singapuri, A.; Immareddy, R.; Ardeshir, A.; Stuart, J.; Bournazos, S.; Ravetch, J.; Balderes, P.; Lorenz, I.; Esswein, S.; Keeffe, J.; Bjorkman, P.; Wang, Q.; Rice, C.; MacDonald, M.; Nussenzweig, M.; Robbiani, D. Michel Nussenzweig
Davide Robbiani
RU
Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in post-mitotic mammalian tissues Nat Commun. 2021 May 25;12(1):3100. doi: 10.1038/s41467-021-23395-3. 34035288 Kastan, N.; Gnedeva, K.; Alisch, T.; Petelski, A.; Huggins, D.; Chiaravalli, J.; Aharanov, A.; Shakked, A.; Tzahor, E.; Nagiel, A.; Segil, N.; Hudspeth, J. James Hudspeth RU
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents Biochemistry 2019, 58, 6, 833-847 30582694 Bythrow, G.; Mohandas, P.; Guney, T.; Standke, L.; Germain, G.; Lu, X.; Ji, C.; Levendosky, K.; Sundaram Chavadi, S.; Tan, D.; Quadri, L. ACKNOWLEDGMENTS: Yasutomi Asano, Makoto Fushimi, Naoyoshi Noguchi, and Michael A. Foley Derek S. Tan MSK
Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration Biol Reprod. 2020 Aug 4;103(2):176-182. doi: 10.1093/biolre/ioaa052. 32307523 Balback, M.; Makoto, F.; Huggins, D.; Steegborn, C.; Meinke. P.; Levin, L.; Buck, J. Lonny Levin, Jochen Buck WCM
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance Proc Natl Acad Sci U S A 115(29):E6863-E6870 29967165 Kirkman, L.; Zhan, W.; Visone, J.; Dziedziech, A.; Singh, P.; Fan, H.; Tong, X.; Bruzual, I.; Hara, R.; Kawasaki, M.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Fernandez-Alvaro, E.; Guiang, L.; Sanz, L.; Mota, D.; Govindasamy, K.; Wang, R.; Ling, Y.; Tumwebaze, P.; Sukenick, G.; Shi, L.; Vendome, J.; Bhanot, P.; Rosenthal, P.; Aso, K.; Foley, M.; Cooper, R.; Kafsack, B.; Doggett, J.; Nathan, C.; Ling, G. Lin WCM
Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome J Med Chem 62(20):9246-9253 31560200 Zhan, W.; Hsu, H.; Morgan, T.; Ouellette, T.; Burns-Huang, K.; Hara, R.; Wright, A.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Ramjee, M.; Aso, K.; Menke, P.; Foley, M.; Nathan, C.; Li, H.; Lin, G. Lin WCM
Inhibition of 3-Phosphoglycerate Dehydrogenase (PHGDH) by Indole Amides Abrogates de novo Serine Synthesis in Cancer Cells Bioorg Med Chem Lett. 2019 Sep 1;29(17):2503-2510 31327531 Mullarky, E.; Xu, J.; Robin, A.; Huggins, D.; Jennings, A.; Noguchi, N.; Olland, A.; Lakshinarasimhan, D.; Miller, M.; Tomita, D.; Michino, M.; Su, T.; Zhang, G.; Stamford, A.; Meinke, P.; Kargman, S.; Cantley, L. Cantley WCM
ALTHEA Gold Libraries™: Antibody libraries for therapeutic antibody discovery MAbs. 2019 Apr;11(3):516-531 30663541 Valadon, P.; Perez-Tapia, S.; Nelson, R.; Guzman-Bringas, O.; Arrieta-Oliva, H.; Gomez-Castellano, K.; Pohl, M.; Almagro, J. Juan Carlos Almagro TDI
Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors J Med Chem 62(13):6137-6145 31177777 Zhan, W.; Visone, J.; Ouellette, T.; Harris, J.; Wang, R.; Zhang, H.; Singh, P.; Ginn, J.; Sukenick, G.; Wong, T; Okoro, J.; Scales, R.; Tumwebaze, P.; Rosenthal, P.; Kafsack, B.; Cooper, R.; Meinke, P.; Kirkman, L.; Lin, G. Gang Lin WCM
A Robust Method for the Purification and Characterization of Recombinant Human Histone H1 Variants Biochemistry. 58(3):171-176 30585724 Osunsade, A.; Prescott, N.; Herbert, J.; Ray, D.; Jmeian, Y.; Lorenz, I.; David, Y David, Yael MSK
Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses ACS Chemical Neuroscience 31313902 Dunn, A.; Reed, B.; Erazo, J.; Ben-Ezra, A.; Kreek, M. Acknowledgement- Mike Miller Kreek RU
Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations ACS Pharmacol Transl Sci. 2019 Aug 2;2(6):387-401 32259072 Li, J.; Fukase, Y.; Yi, S.; Zou, W.; Munoz-Feliz, J.; Buitrago, L.; van Agthoven, J.; Zhang, Y.; Hara, R.; Tanaka, Y.; Okamoto, R.; Yasui, T.; Nakahata, T.; Imaeda, T.; Aso, K.; Zhou, Y.; Locuson, C.; Nesic, D.; Duggan, M.; Takagi, J.; Vaughan, R.; Walz, T.; Hodivala-Dilke, K.; Teitelbaum, S.; Arnaout, M.; Filizola, M.; Foley, M.; Coller, B. Barry Coller RU
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action Elife. 2017 May 19 28524820 Steinman , J.; Santarossa, C.;Miller, R.; Yu, L.; Serpinskaya, A.; Furukawa, H.; Morimoto, S.; Tanaka, Y.; Nishitani, M.; Asano, M.; Zalyte, R.; Ondrus, A.; Johnson, A.; Ye, F.; Nachury, M.; Fukase, Y.; Aso, K.; Foley, M.; Gelfand, V.; Chen, J.; Carter, A.; Kapoor, T. Tarun Kapoor RU
Development of human cGAS-specific small molecule inhibitors for repression of dsDNA-triggered interferon expression Nat Commun. 2019 May 21;10(1):2261 31113940 Lama, L.; Adura, C.; Xie, W.; Tomita, D.; Kamei, T.; Kuryavyi, V.; Gogakos, T.; Steinberg, J.; Miller, M.; Ramos-Espiritu, L.; Asano, Y.; Hashizume, S.; Aida, J.; Imaeda, T.; Okamoto, R.; Jennings, A.;Michino, M.; Kuroita, T.; Stamford, A.; Gao, P.; Meinke, P.; Glickman, J.; Patel, D.; Tuschl, T. Thomas Tuschl RU
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc Natl Acad Sci USA. 2019 Jun 11;116(24):11946-11955 31142647 Xie, W.; Lama, L.; Adura, C.; Tomita, D.; Glickman, F.; Tuschl, T.; Patel, D. Thomas Tuschl RU
Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. Biochemistry. 2018 Feb 27; 57(8): 1399–1409 29394041 Singh PK, Kawasaki M, Berk-Rauch HE, Nishida G, Yamasaki T, Foley MA, Norris EH, Strickland S, Aso K, Ahn HJ. Sid Strckland RU

 

ANNUAL REPORTS2020 | 2019 | 2018 | 2017 | 2016 PUBLICATIONSTitleJournal InformationPMIDAuthorsPIPI InstituteExpression of the mono-ADP-ribosyltransferase ART1 by