Encourage • Empower • Leverage
2020 | 2019 | 2018 | 2017 | 2016
| Title | Journal Information | PMID | Authors | PI | PI Institute |
|---|---|---|---|---|---|
| Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer |
Science Translational Medicine | 35294260 | Tommy White, Abdul Khan, Paul Balderes, Ivo Lorenz | Brendan Stiles | WCM (former |
| Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) | ACS Medicinal Chemistry Letters | 34413957 | Makoto Fushimi, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A Foley, Michael Miller, Nigel J Liverton, David J Huggins, Peter T Meinke | Levin/Buck | WCM |
| Targeting allostery in the Dynein motor domain with small molecule inhibitors | Cell Chemical Biology | 34015309 | Yasuhiro Hirata, Yoshiyuki Fukase | Tarun Kapoor | RU |
| Deglycase-activity oriented screening to identify DJ-1 inhibitors | RSC Medicinal Chemistry | 34355187 | Efrat Finkin-Groner, Yoshiyuki Fukase, Shan Sun, Mayako Michino, David J. Huggins, Robert W. Myers | Yael David | MSK |
| Targeting eIF4A Dependent Translation of KRAS Signaling Molecules | Cancer Res. 2021 Feb 25;canres.2929.2020 | 33632898 | Mark Duggan, Yoshiyuki Fukase, Andrew W. Stamford, Peter T. Meinke | Hans-Guido Wendel | MSK |
| Whole cell active inhibitors of mycobacterial lipoamide dehydrogenase afford selectivity over the human enzyme through tight binding interactions | ACS Infect Dis. 2021 Feb 12;7(2):435-444 | 33527832 | Ginn, John; Sun, Shan; Michino, Mayako; Huggins, David; Liverton, Nigel; Imaeda, Toshihiro; Okamoto, Rei; Kuroita, Takanobu; Aso, Kazuyoshi; Stamford, Andrew; Foley, Michael; Meinke, Peter; | Nathan, Carl; Bryk, Ruslana | WCM |
| Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice | Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9279-9283 | 33433953 | John Ginn, Mayako Michino, Akinori Toita, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Kenjiro Sato, Kazuyoshi Aso, Peter Meinke | Gang Lin, Carl Nathan, Laura Kirkman | WCM |
| Recent Progress in Kappa and Mu Opioid Receptor Targeted Ligands | Medicinal Chemistry Reviews, 2020 Volume 55 | Chapter 4 | Brian Reed, Michael Miller | Mary Jeanne Kreek | WCM |
| A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques | Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7981-7989 | 32209664 | Van Rompay, K.; Coffey, L.; Kapoor, T.; Gazumyan, A.; Keesler, R.; Jurado, A.; Peace, A.; Agudelo, M.; Watanabe, J.; Usachenko, J.; Singapuri, A.; Immareddy, R.; Ardeshir, A.; Stuart, J.; Bournazos, S.; Ravetch, J.; Balderes, P.; Lorenz, I.; Esswein, S.; Keeffe, J.; Bjorkman, P.; Wang, Q.; Rice, C.; MacDonald, M.; Nussenzweig, M.; Robbiani, D. | Michel Nussenzweig Davide Robbiani |
RU |
| Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in post-mitotic mammalian tissues | Nat Commun. 2021 May 25;12(1):3100. doi: 10.1038/s41467-021-23395-3. | 34035288 | Kastan, N.; Gnedeva, K.; Alisch, T.; Petelski, A.; Huggins, D.; Chiaravalli, J.; Aharanov, A.; Shakked, A.; Tzahor, E.; Nagiel, A.; Segil, N.; Hudspeth, J. | James Hudspeth | RU |
| Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents | Biochemistry 2019, 58, 6, 833-847 | 30582694 | Bythrow, G.; Mohandas, P.; Guney, T.; Standke, L.; Germain, G.; Lu, X.; Ji, C.; Levendosky, K.; Sundaram Chavadi, S.; Tan, D.; Quadri, L. ACKNOWLEDGMENTS: Yasutomi Asano, Makoto Fushimi, Naoyoshi Noguchi, and Michael A. Foley | Derek S. Tan | MSK |
| Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration | Biol Reprod. 2020 Aug 4;103(2):176-182. doi: 10.1093/biolre/ioaa052. | 32307523 | Balback, M.; Makoto, F.; Huggins, D.; Steegborn, C.; Meinke. P.; Levin, L.; Buck, J. | Lonny Levin, Jochen Buck | WCM |
| Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance | Proc Natl Acad Sci U S A 115(29):E6863-E6870 | 29967165 | Kirkman, L.; Zhan, W.; Visone, J.; Dziedziech, A.; Singh, P.; Fan, H.; Tong, X.; Bruzual, I.; Hara, R.; Kawasaki, M.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Fernandez-Alvaro, E.; Guiang, L.; Sanz, L.; Mota, D.; Govindasamy, K.; Wang, R.; Ling, Y.; Tumwebaze, P.; Sukenick, G.; Shi, L.; Vendome, J.; Bhanot, P.; Rosenthal, P.; Aso, K.; Foley, M.; Cooper, R.; Kafsack, B.; Doggett, J.; Nathan, C.; Ling, G. | Lin | WCM |
| Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome | J Med Chem 62(20):9246-9253 | 31560200 | Zhan, W.; Hsu, H.; Morgan, T.; Ouellette, T.; Burns-Huang, K.; Hara, R.; Wright, A.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Ramjee, M.; Aso, K.; Menke, P.; Foley, M.; Nathan, C.; Li, H.; Lin, G. | Lin | WCM |
| Inhibition of 3-Phosphoglycerate Dehydrogenase (PHGDH) by Indole Amides Abrogates de novo Serine Synthesis in Cancer Cells | Bioorg Med Chem Lett. 2019 Sep 1;29(17):2503-2510 | 31327531 | Mullarky, E.; Xu, J.; Robin, A.; Huggins, D.; Jennings, A.; Noguchi, N.; Olland, A.; Lakshinarasimhan, D.; Miller, M.; Tomita, D.; Michino, M.; Su, T.; Zhang, G.; Stamford, A.; Meinke, P.; Kargman, S.; Cantley, L. | Cantley | WCM |
| ALTHEA Gold Libraries™: Antibody libraries for therapeutic antibody discovery | MAbs. 2019 Apr;11(3):516-531 | 30663541 | Valadon, P.; Perez-Tapia, S.; Nelson, R.; Guzman-Bringas, O.; Arrieta-Oliva, H.; Gomez-Castellano, K.; Pohl, M.; Almagro, J. | Juan Carlos Almagro | TDI |
| Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors | J Med Chem 62(13):6137-6145 | 31177777 | Zhan, W.; Visone, J.; Ouellette, T.; Harris, J.; Wang, R.; Zhang, H.; Singh, P.; Ginn, J.; Sukenick, G.; Wong, T; Okoro, J.; Scales, R.; Tumwebaze, P.; Rosenthal, P.; Kafsack, B.; Cooper, R.; Meinke, P.; Kirkman, L.; Lin, G. | Gang Lin | WCM |
| A Robust Method for the Purification and Characterization of Recombinant Human Histone H1 Variants | Biochemistry. 58(3):171-176 | 30585724 | Osunsade, A.; Prescott, N.; Herbert, J.; Ray, D.; Jmeian, Y.; Lorenz, I.; David, Y | David, Yael | MSK |
| Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience | 31313902 | Dunn, A.; Reed, B.; Erazo, J.; Ben-Ezra, A.; Kreek, M. Acknowledgement- Mike Miller | Kreek | RU |
| Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations | ACS Pharmacol Transl Sci. 2019 Aug 2;2(6):387-401 | 32259072 | Li, J.; Fukase, Y.; Yi, S.; Zou, W.; Munoz-Feliz, J.; Buitrago, L.; van Agthoven, J.; Zhang, Y.; Hara, R.; Tanaka, Y.; Okamoto, R.; Yasui, T.; Nakahata, T.; Imaeda, T.; Aso, K.; Zhou, Y.; Locuson, C.; Nesic, D.; Duggan, M.; Takagi, J.; Vaughan, R.; Walz, T.; Hodivala-Dilke, K.; Teitelbaum, S.; Arnaout, M.; Filizola, M.; Foley, M.; Coller, B. | Barry Coller | RU |
| Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action | Elife. 2017 May 19 | 28524820 | Steinman , J.; Santarossa, C.;Miller, R.; Yu, L.; Serpinskaya, A.; Furukawa, H.; Morimoto, S.; Tanaka, Y.; Nishitani, M.; Asano, M.; Zalyte, R.; Ondrus, A.; Johnson, A.; Ye, F.; Nachury, M.; Fukase, Y.; Aso, K.; Foley, M.; Gelfand, V.; Chen, J.; Carter, A.; Kapoor, T. | Tarun Kapoor | RU |
| Development of human cGAS-specific small molecule inhibitors for repression of dsDNA-triggered interferon expression | Nat Commun. 2019 May 21;10(1):2261 | 31113940 | Lama, L.; Adura, C.; Xie, W.; Tomita, D.; Kamei, T.; Kuryavyi, V.; Gogakos, T.; Steinberg, J.; Miller, M.; Ramos-Espiritu, L.; Asano, Y.; Hashizume, S.; Aida, J.; Imaeda, T.; Okamoto, R.; Jennings, A.;Michino, M.; Kuroita, T.; Stamford, A.; Gao, P.; Meinke, P.; Glickman, J.; Patel, D.; Tuschl, T. | Thomas Tuschl | RU |
| Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. | Proc Natl Acad Sci USA. 2019 Jun 11;116(24):11946-11955 | 31142647 | Xie, W.; Lama, L.; Adura, C.; Tomita, D.; Glickman, F.; Tuschl, T.; Patel, D. | Thomas Tuschl | RU |
| Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. | Biochemistry. 2018 Feb 27; 57(8): 1399–1409 | 29394041 | Singh PK, Kawasaki M, Berk-Rauch HE, Nishida G, Yamasaki T, Foley MA, Norris EH, Strickland S, Aso K, Ahn HJ. | Sid Strckland | RU |