Encourage • Empower • Leverage
2023 |2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016
| Title | Journal Information | PMID | Authors | PI | PI Institute |
|---|---|---|---|---|---|
| A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques | PNAS 117 (14) 7981-7989 | 32209664 | Michel C. Nussenzweig, Davide F. Robbiani | RU | |
| SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts | Nat Commun 12, 4611 (2021) | 34326333 | Matthew B. Greenblatt | WCM | |
| A TCR mimic monoclonal antibody for the HPV-16 E7-epitope p11-19/HLA-A*02:01 complex | PLoS ONE 17(3), March 17, 2022 | 35298559 | David A. Scheinberg | MSK | |
| A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors | ACS Med. Chem. Lett. 2022, 13, 3, 377–387 | 35300079 | Richard E. Phillips | MSK | |
| Transforming Academic Drug Discovery | Chem Bio Chem, Volume23, Issue8, April 20, 2022 | 35181980 | Peter T. Meinke | TDI | |
| Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates | J. Med. Chem. 2022, 65, 22, 15208–15226 | 36346696 | Levin/ Buck | WCM | |
| A TCR mimic monoclonal antibody reactive with the "public" phospho-neoantigen pIRS2/HLA-A*02:01 complex. | JCI Insight. 2022;7(5):e151624 | 35260532 | David A Scheinberg | MSK | |
| Comparing the Performance of Different AMBER Protein Forcefields, Partial Charge Assignments, and Water Models for Absolute Binding Free Energy Calculations | J. Chem. Theory Comput. 2022, 18, 4, 2616–2630 | 35266690 | David J. Huggins | David J. Huggins | TDI |
| Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors | J. Med. Chem. 2022, 65, 13, 9350–9375 | 35727231 |
Hao Zhang, John Ginn , Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin |
Gang Lin | WCM |
| Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold | ACS Chem. Neurosci. 2022, 13, 13, 1849–1856 | 35738565 |
Brian Reed, Michael Miller, Mayako Michino, Eduardo R. Butelman, Ariel Ben-Ezra, Philip Pikus, Michelle Morochnik, Yuli Kim, Amy Ripka, Joseph Vacca, Mary Jeanne Kreek |
Mary Jeanne Kreek | RU |
| Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs | PNAS, July 8, 2022 | 34035288 |
NathanielR. Kastan, Sanyukta Oak, Rui Liang, Leigh Baxt, Robert W. Myers, John Ginn, Nigel Liverton, David J. Huggins, John Pichardo, Matthew Paul, Thomas S. Carroll, Aaron Nagiel, Ksenia Gnedeva, A. J. Hudspeth |
A. J. Hudspeth | RU |
| Assessing the effect of forcefield parameter sets on the accuracy of relative binding free energy calculations | Front. Mol. Biosci., 12 September 2022 | 36225254 | Shan Sun, David J. Huggins | David J. Huggins | TDI |
| Small-molecule inhibition of the acyl-lysine reader ENL as a strategy against acute myeloid leukemia. | Cacer Discovery, Nov. 2, 2022 | 36053276 |
Yiman Liu, Qinglan Li, Fatemeh Alikarami, Declan R. Barrett, Leila Mahdavi, Hangpeng Li, Sylvia Tang, Tanweer A. Khan, Mayako Michino, Connor Hill, Lele Song, Lu Yang, Yuanyuan Li, Sheela Pangeni Pokharel, Andrew W. Stamford, Nigel Liverton, Louis M. Renzetti, Simon Taylor, Gillian F. Watt, Tammy Ladduwahetty, Stacia Kargman, Peter T. Meinke, Michael A. Foley, Junwei Shi, Haitao Li, Martin Carroll, Chun-Wei Chen, Alessandro Gardini, Ivan Maillard, David J. Huggins, Kathrin M. Bernt, Liling Wan |
Liling Wan | RU |
| Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential | Front. Physiol., 28 September 2022 | 36246105 |
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck |
Lonny R. Levin, Jochen Buck | WCM |
| Neuropeptide regulation of non-redundant ILC2 responses and tissue homeostasis | Nature, Nov. 2, 2022 | 36323781 |
Amy M. Tsou, Hiroshi Yano, Christopher N. Parkhurst, Tanel Mahlakõiv, Coco Chu, Wen Zhang, Zhengxiang He, Katja J. Jarick, Connie Zhong, Gregory G. Putzel, Mai Hatazaki, JRI IBD Live Cell Bank Consortium, Ivo C. Lorenz, David Andrew, Paul Balderes, Christoph S. N. Klose, Sergio A. Lira David Artis |
David Artis | WCM |
| Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer |
Science Translational Medicine | 35294260 | Tommy White, Abdul Khan, Paul Balderes, Ivo Lorenz | Brendan Stiles | WCM (former |
| Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization | Molecular Human Reproduction, Volume 27, Issue 9, September 2021 | 34463764 | Melanie Balbach, Lubna Ghanem, Thomas Rossetti, Navpreet Kaur, Carla Ritagliati, Jacob Ferreira, Dario Krapf, Lis C Puga Molina, Celia Maria Santi, Jan Niklas Hansen, Dagmar Wachten, Makoto Fushimi, Peter T Meinke, Jochen Buck, Lonny R Levin |
Buck/ Levin | WCM |
| Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) | ACS Medicinal Chemistry Letters | 34413957 | Makoto Fushimi, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A Foley, Michael Miller, Nigel J Liverton, David J Huggins, Peter T Meinke | Levin/Buck | WCM |
| Targeting allostery in the Dynein motor domain with small molecule inhibitors | Cell Chemical Biology | 34015309 | Yasuhiro Hirata, Yoshiyuki Fukase | Tarun Kapoor | RU |
| Deglycase-activity oriented screening to identify DJ-1 inhibitors | RSC Medicinal Chemistry | 34355187 | Efrat Finkin-Groner, Yoshiyuki Fukase, Shan Sun, Mayako Michino, David J. Huggins, Robert W. Myers | Yael David | MSK |
| Targeting eIF4A Dependent Translation of KRAS Signaling Molecules | Cancer Res. 2021 Feb 25;canres.2929.2020 | 33632898 | Mark Duggan, Yoshiyuki Fukase, Andrew W. Stamford, Peter T. Meinke | Hans-Guido Wendel | MSK |
| Whole cell active inhibitors of mycobacterial lipoamide dehydrogenase afford selectivity over the human enzyme through tight binding interactions | ACS Infect Dis. 2021 Feb 12;7(2):435-444 | 33527832 | Ginn, John; Sun, Shan; Michino, Mayako; Huggins, David; Liverton, Nigel; Imaeda, Toshihiro; Okamoto, Rei; Kuroita, Takanobu; Aso, Kazuyoshi; Stamford, Andrew; Foley, Michael; Meinke, Peter | Nathan, Carl; Bryk, Ruslana | WCM |
| Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice | Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9279-9283 | 33433953 | John Ginn, Mayako Michino, Akinori Toita, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Kenjiro Sato, Kazuyoshi Aso, Peter Meinke | Gang Lin, Carl Nathan, Laura Kirkman | WCM |
| Recent Progress in Kappa and Mu Opioid Receptor Targeted Ligands | Medicinal Chemistry Reviews, 2020 Volume 55 | Chapter 4 | Brian Reed, Michael Miller | Mary Jeanne Kreek | WCM |
| A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques | Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7981-7989 | 32209664 | Van Rompay, K.; Coffey, L.; Kapoor, T.; Gazumyan, A.; Keesler, R.; Jurado, A.; Peace, A.; Agudelo, M.; Watanabe, J.; Usachenko, J.; Singapuri, A.; Immareddy, R.; Ardeshir, A.; Stuart, J.; Bournazos, S.; Ravetch, J.; Balderes, P.; Lorenz, I.; Esswein, S.; Keeffe, J.; Bjorkman, P.; Wang, Q.; Rice, C.; MacDonald, M.; Nussenzweig, M.; Robbiani, D. | Michel Nussenzweig Davide Robbiani |
RU |
| Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in post-mitotic mammalian tissues | Nat Commun. 2021 May 25;12(1):3100. doi: 10.1038/s41467-021-23395-3. | 34035288 | Kastan, N.; Gnedeva, K.; Alisch, T.; Petelski, A.; Huggins, D.; Chiaravalli, J.; Aharanov, A.; Shakked, A.; Tzahor, E.; Nagiel, A.; Segil, N.; Hudspeth, J. | James Hudspeth | RU |
| Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents | Biochemistry 2019, 58, 6, 833-847 | 30582694 | Bythrow, G.; Mohandas, P.; Guney, T.; Standke, L.; Germain, G.; Lu, X.; Ji, C.; Levendosky, K.; Sundaram Chavadi, S.; Tan, D.; Quadri, L. ACKNOWLEDGMENTS: Yasutomi Asano, Makoto Fushimi, Naoyoshi Noguchi, and Michael A. Foley | Derek S. Tan | MSK |
| Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration | Biol Reprod. 2020 Aug 4;103(2):176-182. doi: 10.1093/biolre/ioaa052. | 32307523 | Balback, M.; Makoto, F.; Huggins, D.; Steegborn, C.; Meinke. P.; Levin, L.; Buck, J. | Lonny Levin, Jochen Buck | WCM |
| Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance | Proc Natl Acad Sci U S A 115(29):E6863-E6870 | 29967165 | Kirkman, L.; Zhan, W.; Visone, J.; Dziedziech, A.; Singh, P.; Fan, H.; Tong, X.; Bruzual, I.; Hara, R.; Kawasaki, M.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Fernandez-Alvaro, E.; Guiang, L.; Sanz, L.; Mota, D.; Govindasamy, K.; Wang, R.; Ling, Y.; Tumwebaze, P.; Sukenick, G.; Shi, L.; Vendome, J.; Bhanot, P.; Rosenthal, P.; Aso, K.; Foley, M.; Cooper, R.; Kafsack, B.; Doggett, J.; Nathan, C.; Lin, G. | Gang Lin | WCM |
| Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome | J Med Chem 62(20):9246-9253 | 31560200 | Zhan, W.; Hsu, H.; Morgan, T.; Ouellette, T.; Burns-Huang, K.; Hara, R.; Wright, A.; Imaeda, T.; Okamoto, R.; Sato, K.; Michino, M.; Ramjee, M.; Aso, K.; Menke, P.; Foley, M.; Nathan, C.; Li, H.; Lin, G. | Gang Lin | WCM |
| Inhibition of 3-Phosphoglycerate Dehydrogenase (PHGDH) by Indole Amides Abrogates de novo Serine Synthesis in Cancer Cells | Bioorg Med Chem Lett. 2019 Sep 1;29(17):2503-2510 | 31327531 | Mullarky, E.; Xu, J.; Robin, A.; Huggins, D.; Jennings, A.; Noguchi, N.; Olland, A.; Lakshinarasimhan, D.; Miller, M.; Tomita, D.; Michino, M.; Su, T.; Zhang, G.; Stamford, A.; Meinke, P.; Kargman, S.; Cantley, L. | Lewis Cantley | WCM |
| ALTHEA Gold Libraries™: Antibody libraries for therapeutic antibody discovery | MAbs. 2019 Apr;11(3):516-531 | 30663541 | Valadon, P.; Perez-Tapia, S.; Nelson, R.; Guzman-Bringas, O.; Arrieta-Oliva, H.; Gomez-Castellano, K.; Pohl, M.; Almagro, J. | Mary Ann Pohl | TDI |
| Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors | J Med Chem 62(13):6137-6145 | 31177777 | Zhan, W.; Visone, J.; Ouellette, T.; Harris, J.; Wang, R.; Zhang, H.; Singh, P.; Ginn, J.; Sukenick, G.; Wong, T; Okoro, J.; Scales, R.; Tumwebaze, P.; Rosenthal, P.; Kafsack, B.; Cooper, R.; Meinke, P.; Kirkman, L.; Lin, G. | Gang Lin | WCM |
| A Robust Method for the Purification and Characterization of Recombinant Human Histone H1 Variants | Biochemistry. 58(3):171-176 | 30585724 | Osunsade, A.; Prescott, N.; Herbert, J.; Ray, D.; Jmeian, Y.; Lorenz, I.; David, Y | David, Yael | MSK |
| Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience | 31313902 | Dunn, A.; Reed, B.; Erazo, J.; Ben-Ezra, A.; Kreek, M. Acknowledgement- Mike Miller | Kreek | RU |
| Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations | ACS Pharmacol Transl Sci. 2019 Aug 2;2(6):387-401 | 32259072 | Li, J.; Fukase, Y.; Yi, S.; Zou, W.; Munoz-Feliz, J.; Buitrago, L.; van Agthoven, J.; Zhang, Y.; Hara, R.; Tanaka, Y.; Okamoto, R.; Yasui, T.; Nakahata, T.; Imaeda, T.; Aso, K.; Zhou, Y.; Locuson, C.; Nesic, D.; Duggan, M.; Takagi, J.; Vaughan, R.; Walz, T.; Hodivala-Dilke, K.; Teitelbaum, S.; Arnaout, M.; Filizola, M.; Foley, M.; Coller, B. | Barry Coller | RU |
| Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action | Elife. 2017 May 19 | 28524820 | Steinman , J.; Santarossa, C.;Miller, R.; Yu, L.; Serpinskaya, A.; Furukawa, H.; Morimoto, S.; Tanaka, Y.; Nishitani, M.; Asano, M.; Zalyte, R.; Ondrus, A.; Johnson, A.; Ye, F.; Nachury, M.; Fukase, Y.; Aso, K.; Foley, M.; Gelfand, V.; Chen, J.; Carter, A.; Kapoor, T. | Tarun Kapoor | RU |
| Development of human cGAS-specific small molecule inhibitors for repression of dsDNA-triggered interferon expression | Nat Commun. 2019 May 21;10(1):2261 | 31113940 | Lama, L.; Adura, C.; Xie, W.; Tomita, D.; Kamei, T.; Kuryavyi, V.; Gogakos, T.; Steinberg, J.; Miller, M.; Ramos-Espiritu, L.; Asano, Y.; Hashizume, S.; Aida, J.; Imaeda, T.; Okamoto, R.; Jennings, A.;Michino, M.; Kuroita, T.; Stamford, A.; Gao, P.; Meinke, P.; Glickman, J.; Patel, D.; Tuschl, T. | Thomas Tuschl | RU |
| Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. | Proc Natl Acad Sci USA. 2019 Jun 11;116(24):11946-11955 | 31142647 | Xie, W.; Lama, L.; Adura, C.; Tomita, D.; Glickman, F.; Tuschl, T.; Patel, D. | Thomas Tuschl | RU |
| Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. | Biochemistry. 2018 Feb 27; 57(8): 1399–1409 | 29394041 | Singh PK, Kawasaki M, Berk-Rauch HE, Nishida G, Yamasaki T, Foley MA, Norris EH, Strickland S, Aso K, Ahn HJ. | Sid Strckland | RU |
| Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1 | Proc Natl Acad Sci U S A. 2020 Aug 4; 117(31): 18459–18469. | 32694211 | Keith J. Mickolajczyk Paul Dominic B. Olinares, Yiming Niu, Nan Chen, Sara E. Warrington,Yusuke Sasaki, Thomas Walz, Brian T. Chait, Tarun M. Kapoor | Tarun M. Kapoor | RU |
| Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055 |
ACS Med. Chem. Lett. 2024, 15, 4, 524–532
Publication Date:March 12, 2024
|
|
C. David Allis | RU | |
| Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome. |
J Med Chem. 2021 May 13;64(9):6262-6272
|
33949190 | Zhang H, Hsu HC, Kahne SC, Hara R, Zhan W, Jiang X, Burns-Huang K, Ouellette T, Imaeda T, Okamoto R, Kawasaki M, Michino M, Wong TT, Toita A, Yukawa T, Moraca F, Vendome J, Saha P, Sato K, Aso K, Ginn J, Meinke PT, Foley M, Nathan CF, Darwin KH, Li H, Lin | Gang Lin | WCM |
| Neuropeptide regulation of non-redundant ILC2 responses at barrier surface |
Nature. 2022 Nov;611(7937):787-793
|
36323781 | Tsou AM, Yano H, Parkhurst CN, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M; JRI IBD Live Cell Bank Consortium; Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. | David Artis | WCM |
| Computational Fluorine Scanning Using Free-Energy Perturbation |
J. Chem. Inf. Model. 2019, 59, 6, 2776–2784
Publication Date:May 2, 2019
|
Alexander D. Wade, Andrea Rizzi, Yuanqing Wang, and David J. Huggins | David J. Huggins | TDI | |
| Optimization of Protein-Ligand Electrostatic Interactions Using an Alchemical Free-Energy Method |
J. Chem. Theory Comput. 2019, 15, 11, 6504–6512
Publication Date:October 4, 2019
|
Alexander D. Wade and David J. Huggins | David J. Huggins | TDI | |
Identification of Optimal Ligand Growth Vectors Using an Alchemical Free-Energy Method |
J. Chem. Inf. Model. 2020, 60, 11, 5580–5594
Publication Date:August 18, 2020
|
Alexander D. Wade and David J. Huggins | David J. Huggins | TDI | |
| Structural analysis of experimental drugs binding to the SARS-CoV-2 targetTMPR2 |
J Mol Graph Model. 2020 Nov; 100: 107710
|
|
David J. Huggins | David J. Huggins | TDI |
| Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes |
Methods Enzymol. 2020;638:69-87
|
32416922 | Kinarivala N, Standke LC, Guney T, Ji C, Noguchi N, Asano Y, Tan D | Derek Tan | MSK |
| Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice |
Nat Commun. 2017 Sep 29;8(1):750.
|
28963528 | Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M. | Thomas Tuschl | RU |
| Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. |
Nat Commun. 2017 Nov 23;8(1):1827.
|
29170402 | Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M. | Thomas Tuschl | RU |
| On-demand male contraception via acute inhibition of soluble adenylyl cyclase. |
Nat Commun. 2023 Feb 14;14(1):637.
|
36788210 | Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT, Buck J, Levin LR. | Lonny Levin/ Jocken Buck | WCM |
| Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II |
J Med Chem. 2023 Jan 26;66(2):1484-1508
|
33630286 | Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Liverton N, Foley M, Meinke PT, Nathan CF, Kirkman LA, Lin G. | Gang Lin | WCM |
Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies. |
Nat Microbiol. 2023 Jun;8(6):1051-1063.
|
37188812 | Zhang F, Jenkins J, de Carvalho RVH, Nakandakari-Higa S, Chen T, Abernathy ME, Baharani VA, Nyakatura EK, Andrew D, Lebedeva IV, Lorenz IC, Hoffmann HH, Rice CM, Victora GD, Barnes CO, Hatziioannou T, Bieniasz PD. | Paul Bieniasz & Theodora Hatziioannou | RU |
| Enhancing Hit Discovery in Virtual Screening through Absolute Protein-Ligand Binding Free-Energy Calculations. |
J Chem Inf Model. 2023 May 22;63(10):3171-3185.
|
37167486 | Chen W, Cui D, Jerome SV, Michino M, Lenselink EB, Huggins DJ, Beautrait A, Vendome J, Abel R, Friesner RA, Wang L. | Mayako Michino | TDI |
| Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors |
ACS Bio Med Chem Au. 2023 Sep 8;3(6):507-515
|
38144256 | Michino M, Beautrait A, Boyles NA, Nadupalli A, Dementiev A, Sun S, Ginn J, Baxt L, Suto R, Bryk R, Jerome SV, Huggins DJ, Vendome J. | David Huggins | TDI |
| Biochemical and structural analysis of the interaction between β-amyloid and fibrinogen. |
Blood. 2016 Aug 25;128(8):1144-51.
|
27389717 | Zamolodchikov D, Berk-Rauch HE, Oren DA, Stor DS, Singh PK, Kawasaki M, Aso K, Strickland S, Ahn HJ | Sid Strikland | RU |
| A Semisynthetic Kanglemycin Shows In Vivo Efficacy against High-Burden Rifampicin Resistant Pathogens. |
ACS Infect Dis. 2020 Sep 11;6(9):2431-2440.
|
32786275 | Peek J, Xu J, Wang H, Suryavanshi S, Zimmerman M, Russo R, Park S, Perlin DS, Brady SF. | Sean Brady | RU |
| Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes. |
J Am Chem Soc. 2024 Jan 10;146(1):62-67.
|
38134034 | Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. | Tarun Kapoor | RU |
| Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior |
Parasit Vectors. 2024 Jun 28;17(1):276. doi: 10.1186/s13071-024-06347-w.
|
38937807 | Zeledon EV, Baxt LA, Khan TA, Michino M, Miller M, Huggins DJ, Jiang CS, Vosshall LB, Duvall LB. | Leslie B Vosshall | RU |
| Developing a membrane-proximal CD33-targeting CAR T cell |
J Immunother Cancer. 2024 May 20;12(5):e009013. doi: 10.1136/jitc-2024-009013
|
38772686 | Freeman R, Shahid S, Khan AG, Mathew SC, Souness S, Burns ER, Um JS, Tanaka K, Cai W, Yoo S, Dunbar A, Park Y, McAvoy D, Hosszu KK, Levine RL, Boelens JJ, Lorenz IC, Brentjens RJ, Daniyan AF. | Anthony F Daniyan & Renier Brentjens | MSK |
| Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies |
Nat Microbiol. 2023 Jun;8(6):1051-1063. doi: 10.1038/s41564-023-01389-9.
|
37188812 | Zhang F, Jenkins J, de Carvalho RVH, Nakandakari-Higa S, Chen T, Abernathy ME, Baharani VA, Nyakatura EK, Andrew D, Lebedeva IV, Lorenz IC, Hoffmann HH, Rice CM, Victora GD, Barnes CO, Hatziioannou T, Bieniasz PD. | Theodora Hatziioannou & Paul Bieniasz | RU |
| A TCR mimic monoclonal antibody reactive with the “public” phospho-neoantigen pIRS2/HLA-A*02:01 complex |
JCI Insight. 2022 Mar 8;7(5):e151624. doi: 10.1172/jci.insight.151624
|
35260532 | Dao T, Mun SS, Molvi Z, Korontsvit T, Klatt MG, Khan AG, Nyakatura EK, Pohl MA, White TE, Balderes PJ, Lorenz IC, O'Reilly RJ, Scheinberg DA. | David A. Scheinberg | MSK |
| 89Zr-immunoPET-guided selection of a CD33xIL15 fusion protein optimized for antitumor immune cell activation and in vivo tumour retention in acute myeloid leukaemia |
Eur J Nucl Med Mol Imaging. 2024 Jul 11. doi: 10.1007/s00259-024-06814-7
|
38987489 | Herrero Alvarez N, Molvi Z, Lupo K, Urraca J, Balderes P, Nyakatura EK, Khan AG, Viray T, Lewis JS, O'Reilly RJ. | Jason Lewis & Richard O'Reilly | MSK |
| BAT2: an Open-Source Tool for Flexible, Automated, and Low Cost Absolute Binding Free Energy Calculations |
J Chem Theory Comput. 2024 Aug. 13;20(15):6518-6530
|
39088306 |
Germano Heinzelmann, David J. Huggins, Michael K. Gilson |
||
| Indazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity. |
Angew Chem Int Ed Engl, 2024
|
38997232 | Dr. Shan Sun, Dr. John Ginn, Dr. Tomasz Kochanczyk, Nancy Arango, Xiuju Jiang, Dr. David J. Huggins, Dr. James Bean, Dr. Mayako Michino, Dr. Leigh Baxt, Dr. Nigel Liverton, Dr. Peter T. Meinke, Dr. Ruslana Bryk | ||
| The benefits of translating biomedical research at drug discovery institutes |
Nature Reviews Drug Discovery; 2024 Sep 26
|
39327502 |
David J. Huggins, Jonathan Baell, Paul E. Brennan, Alex Burgin & Duncan E. Scott |
||
| Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase |
Nature; 2024 Dec 11
|
39663451 |
Meyer C, Garzia A, Miller MW, Huggins DJ, Myers RW, Hoffmann HH, Ashbrook AW, Jannath SY, Liverton N, Kargman S, Zimmerman M, Nelson AM, Sharma V, Dolgov E, Cangialosi J, Penalva-Lopez S, Alvarez N, Chang CW, Oswal N, Gonzalez I, Rasheed R, Goldgirsh K, Davis JA, Ramos-Espiritu L, Menezes MR, Larson C, Nitsche J, Ganichkin O, Alwaseem H, Molina H, Steinbacher S, Glickman JF, Perlin DS, Rice CM, Meinke PT, Tuschl T. |